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Kidney cancer

Assessing the management of localized kidney cancer

Studies have reported an increase in the use of nephron-sparing surgery (NSS) since 2002, but quality of life (QOL) may be decreased in patients managed with partial versus radical nephrectomy. These reports have highlighted existing challenges in ensuring delivery of NSS in appropriate candidates while balancing risks to mortality, morbidity and QOL.

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References

  1. Go, A. S., Chertow, G. M., Fan, D., McCulloch, C. E. & Hsu, C. Y. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N. Engl. J. Med. 351, 1296–1305 (2004).

    CAS  Google Scholar 

  2. Huang, W. C. et al. Chronic kidney disease after nephrectomy in patients with renal cortical tumors: a retrospective cohort study. Lancet Oncol. 7, 735–740 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Campbell, S. C. et al. Guideline for management of the clinical T1 renal mass. J. Urol. 182, 1271–1279 (2009).

    Article  PubMed  Google Scholar 

  4. Patel, S. G. et al. National trends in the use of partial nephrectomy: a rising tide that has not lifted all boats. J. Urol. 187, 816–822 (2012).

    Article  PubMed  Google Scholar 

  5. Kim, S. P. et al. Contemporary trends in nephrectomy for renal cell carcinoma in the United States: results from a population based cohort. J. Urol. 186, 1779–1785 (2011).

    Article  PubMed  Google Scholar 

  6. Filson, C. P. et al. Surgeon characteristics and long-term trends in the adoption of laparoscopic radical nephrectomy. J. Urol. 185, 2072–2077 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Van Poppel, H. et al. A prospective, randomised EORTC intergroup phase 3 study comparing the oncologic outcome of elective nephron-sparing surgery and radical nephrectomy for low-stage renal cell carcinoma. Eur. Urol. 59, 543–552 (2011).

    Article  PubMed  Google Scholar 

  8. Kutikov, A., Smaldone, M. C., Egleston, B. L. & Uzzo, R. G. Should partial nephrectomy be offered to all patients whenever technically feasible? Eur. Urol. 61, 732–734 (2012).

    Article  PubMed  Google Scholar 

  9. Parker, P. A. et al. Comprehensive assessment of quality of life and psychosocial adjustment in patients with renal tumors undergoing open, laparoscopic and nephron sparing surgery. J. Urol. 187, 822–826 (2012).

    Article  PubMed  Google Scholar 

  10. Smaldone, M. C. et al. Small renal masses progressing to metastases under active surveillance: a systematic review and pooled analysis. Cancer 118, 997–1006 (2012).

    Article  PubMed  Google Scholar 

Download references

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Correspondence to Alexander Kutikov.

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Smaldone, M., Kutikov, A. Assessing the management of localized kidney cancer. Nat Rev Urol 9, 186–188 (2012). https://doi.org/10.1038/nrurol.2012.45

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