A recent study shows that recommended bone mineral testing is rarely performed in men with prostate cancer receiving androgen deprivation therapy. Although these patients are at increased risk of fragility fracture, the reported incidence, from prospective randomized trials, is low. As a result, bone density testing for these men requires careful consideration.
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References
NCCN Clinical Practice Guidelines in Oncology™. Prostate cancer [online], (2008).
Morgans, A. K., Smith, M. R., O'Malley, A. J. & Keating, N. L. Bone density testing among prostate cancer survivors treated with androgen-deprivation therapy. Cancer http://dx.doi.org/10.1002/cncr.27830.
National Osteoporosis Foundation. NOF Clinician's guide to prevention and treatment of osteoporosis [online], (2010).
Smith, M. R. et al. Denosumab in men receiving androgen-deprivation therapy for prostate cancer. N. Engl. J. Med. 361, 745–755 (2009).
Oefelein, M. G., Ricchiuti, V., Conrad, W. & Resnick, M. I. Skeletal fractures negatively correlate with overall survival in men with prostate cancer. J. Urol. 168, 1005–1007 (2002).
WHO Collaborating Centre for Metabolic Bone Diseases. WHO Fracture Risk Assessment Tool (FRAX®) [online], (2012).
Planas, J. et al. Alendronate decreases the fracture risk in patients with prostate cancer on androgen-deprivation therapy and with severe osteopenia or osteoporosis. BJU Int. 104, 1637–1640 (2009).
Smith, M. R. et al. Pamidronate to prevent bone loss during androgen-deprivation therapy for prostate cancer. N. Engl. J. Med. 345, 948–955 (2001).
Michaelson, M. D. et al. Randomized controlled trial of annual zoledronic acid to prevent gonadotropin-releasing hormone agonist-induced bone loss in men with prostate cancer. J. Clin. Oncol. 25, 1038–1042 (2007).
Yu, E. Y. et al. Long-term dynamics of bone mineral density during intermittent androgen deprivation for men with nonmetastatic, hormone-sensitive prostate cancer. J. Clin. Oncol. 30, 1864–1870 (2012).
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Yu, E. Bone density testing—essential or extraneous?. Nat Rev Urol 10, 11–12 (2013). https://doi.org/10.1038/nrurol.2012.240
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DOI: https://doi.org/10.1038/nrurol.2012.240