Research has revealed what we already suspected—randomized controlled trials are lacking in the field of bladder cancer. Many areas require further investigation, and we must try to incentivize clinicians to perform the much-needed trials. A newly established patient advocacy group will be invaluable in this endeavour.
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References
- 1
Bachir, B. G. et al. Demographic analysis of randomized controlled trials in bladder cancer. BJU Int. http://dx.doi.org/10.1111/j.1464-410X.2012.11401.x.
- 2
Jemal, A. et al. Cancer Statistics, 2008. CA Cancer J. Clin. 58, 71–96 (2008).
- 3
Ries, L. A. G. et al. SEER Cancer Statistics Review, 1975–2004 [online], (2007).
- 4
Heney, N. M. et al. Superficial bladder cancer: progression and recurrence. J. Urol. 130, 1083–1086 (1983).
- 5
Lotan, Y. et al. Key concerns about the current state of bladder cancer: a position paper from the Bladder Cancer Think Tank, the Bladder Cancer Advocacy Network, and the Society of Urologic Oncology. Cancer 115, 4096–4103 (2009).
- 6
Soloway, M. S., Bruck, D. S. & Kim, S. S. Expectant management of small, recurrent, noninvasive papillary bladder tumors. J. Urol. 170, 438–441 (2003).
- 7
Herr, H. W. Does cystoscopy correlate with the histology of recurrent papillary tumours of the bladder? BJU Int. 88, 683–685 (2001).
- 8
Babjuk, M. et al. EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder. Eur. Urol. 54, 303–314 (2008).
- 9
Schmitz-Drager, B. J. et al. in Bladder Cancer 2nd Edn (eds Soloway, M. & Khoury, S.) 171–205 (European Association of Urology, Paris, 2012).
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The author declares he has acted as a consultant and received grant/research support (inc. clinical trials) from Allergan, Photocure and Sanofi-Aventis.
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Soloway, M. Lack of progress in bladder cancer—what are the obstacles?. Nat Rev Urol 10, 5–6 (2013). https://doi.org/10.1038/nrurol.2012.219
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