Androgen deprivation therapy (ADT) is well established as a cause of osteoporosis and increased fracture risk. A study has shown that toremifene reduces fracture risk in men receiving ADT for prostate cancer. The study has substantial limitations, however, and the management of bone disease in these patients remains a challenge.
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Shahinian, V. Reducing fracture risk in men on androgen deprivation therapy. Nat Rev Urol 8, 9–10 (2011). https://doi.org/10.1038/nrurol.2010.210
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DOI: https://doi.org/10.1038/nrurol.2010.210
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