Hypothyroidism is a commonly reported side effect of treatment with sunitinib and sorafenib. A recent study has correlated development of subclinical hypothyroidism with clinical outcome, notably response rate and overall survival, in patients with metastatic renal cell carcinoma who are being treated with these drugs.
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The author declares an association with Pfizer, for whom he acts as a consultant and receives research funding.
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Rini, B. Kidney cancer: Does hypothyroidism predict clinical outcome?. Nat Rev Urol 8, 10–11 (2011). https://doi.org/10.1038/nrurol.2010.191
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DOI: https://doi.org/10.1038/nrurol.2010.191