Late-onset hypogonadism (LOH) is frequently difficult to diagnose in middle-aged and elderly men. A recent study has reported that a cluster of three sexual symptoms and a total testosterone threshold of less than 11 nmol/l are important determinants for the diagnosis of LOH in this age group.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Applying machine learning techniques to the identification of late-onset hypogonadism in elderly men
SpringerPlus Open Access 16 June 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Wang, C. et al. Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA, and ASA recommendations. J. Androl. 30, 1–9 (2009).
Wu, F. C. W. et al. Identification of late-onset hypogonadism in middle-aged and elderly men. N. Engl. J. Med. 363, 123–125 (2010).
Bhasin, S. et al. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 95, 2536–2559 (2010).
Zitzmann, M., Faber, S. & Nieschlag, E. Association of specific symptoms and metabolic risks with serum testosterone in older men. J. Clin. Endocrinol. Metab. 91, 4335–4343 (2006).
Zitzmann, M. Mechanisms of disease: pharmacogenetics of testosterone therapy in hypogonadal men. Nat. Clin. Pract. Urol. 4, 161–166 (2007).
Stanworth, R. D., Kapoor, D., Channer, K. S. & Jones, T. H. Androgen receptor CAG polymorphism is associated with serum testosterone levels, obesity and serum leptin in men with type 2 diabetes. Eur. J. Endocrinol. 159, 739–746 (2008).
Araujo, A. B. et al. Prevalence of symptomatic androgen deficiency in men. J. Clin. Endocrinol. Metab. 92, 4241–4247 (2007).
Wu, F. C. et al. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male aging Study. J. Clin. Endocrinol. Metab. 93, 2737–2745 (2008).
Kapoor, D., Aldred, H., Clark, S., Channer, K. S. & Jones, T. H. Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: correlations with bioavailable testosterone and visceral adiposity. Diabetes Care 30, 911–917 (2007).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
T. H. Jones declares that he has received speakers bureau honoraria and grant/research support from Bayer Schering Pharma, and has received speakers bureau honoraria and acted as a consultant for ProStraken.
Rights and permissions
About this article
Cite this article
Jones, T. Identifying late-onset hypogonadism in older men. Nat Rev Urol 7, 599–601 (2010). https://doi.org/10.1038/nrurol.2010.162
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrurol.2010.162
