Initial results of the REDUCE trial suggest that dutasteride decreases the incidence of prostate cancer in men with persistently elevated PSA; however, questions have emerged about the drug's effect on the incidence of high-grade cancer. Adjustment for post-randomization confounders, however, brings the true benefit of this drug into clearer focus.
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Gann, P. A closer look at the initial results from the REDUCE trial. Nat Rev Urol 7, 535–537 (2010). https://doi.org/10.1038/nrurol.2010.144
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DOI: https://doi.org/10.1038/nrurol.2010.144