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Prostate cancer

Defining biochemical failure in patients treated with HIFU

No established definition exists of therapeutic success after high-intensity focused ultrasound in patients with localized prostate cancer. A recent analysis has proposed a definition of biochemical failure for use in this setting. However, much work still needs to be done on identifying suitable predictors of clinical failure, and large-scale validation is certainly required.

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References

  1. Chavrier, F. et al. Modeling of HIFU induced lesions in the presence of cavitation bubbles. J. Acoust. Soc. Am. 108, 432–440 (2000).

    Article  CAS  PubMed  Google Scholar 

  2. Poissonnier, L. et al. Control of prostate cancer by transrectal HIFU in 227 patients. Eur. Urol. 51, 381–387 (2007).

    Article  CAS  PubMed  Google Scholar 

  3. Gelet, A. et al. Transrectal high intensity focused ultrasound for the treatment of localised prostate cancer: factors influencing the outcome. Eur. Urol. 40, 124–129 (2001).

    Article  CAS  PubMed  Google Scholar 

  4. Thüroff, S. et al. High intensity focused ultrasound and localized prostate cancer: efficacy results from the European multicentric study. J. Endourol. 17, 673–677 (2003).

    Article  PubMed  Google Scholar 

  5. Chaussy, C. & Thüroff, S. The status of high-intensity focused ultrasound in the treatment of localized prostate cancer and the impact of a combined resection. Curr. Urol. Rep. 4, 248–252 (2003).

    Article  PubMed  Google Scholar 

  6. Blana, A. et al. Eight years' experience with high-intensity focused ultrasonography for treatment of localized prostate cancer. Urology 72, 1329–1333 (2008).

    Article  PubMed  Google Scholar 

  7. Ganzer, R. et al. PSA nadir is a significant predictor of treatment failure after high-intensity focused ultrasound (HIFU) treatment of localised prostate cancer. Eur. Urol. 53, 547–553 (2008).

    Article  CAS  PubMed  Google Scholar 

  8. Blana, A. et al. High-intensity focused ultrasound for prostate cancer: comparative definitions of biochemical failure. BJU Int. 104, 1058–1062 (2009).

    Article  CAS  PubMed  Google Scholar 

  9. Roach, M. III et al. Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations of the RTOG-ASTRO Phoenix Consensus Conference. Int. J. Radiat. Oncol. Biol. Phys. 65, 965–974 (2006).

    Article  PubMed  Google Scholar 

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Correspondence to May Abdel-Wahab.

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Competing interests

A. Pollack has received honoraria from General Electric for participating in a speakers bureau. M. Abdel-Wahab declares no competing interests.

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Abdel-Wahab, M., Pollack, A. Defining biochemical failure in patients treated with HIFU. Nat Rev Urol 7, 186–187 (2010). https://doi.org/10.1038/nrurol.2010.12

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