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Prostate Cancer

Regeneration of interest in the prostate

Nature Reviews Urology volume 6, pages 184–186 (2009)Cite this article

The growth of prostate acini from single cell implants in mice is a major breakthrough. Such results have important clinical implications, and will ultimately change the treatment paradigm for prostatic disease.

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Figure 1: The single-cell transplantation procedure.
Figure 2: Multiple prostate epithelial cell types derived from a stem cell transplant.

References

  1. Leong, K. G., Wang, B. E., Johnson, L. & Gao, W. Q. Generation of a prostate from a single adult stem cell. Nature 456, 804–808 (2008).

    Article  CAS  PubMed  Google Scholar 

  2. Isaacs, J. T. & Coffey, D. S. Etiology and disease process of benign prostatic hyperplasia. Prostate Suppl. 2, 33–50 (1989).

    Article  CAS  PubMed  Google Scholar 

  3. Burger, P. E. et al. Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue. Proc. Natl Acad. Sci. USA 102, 7180–7185 (2005).

    Article  CAS  PubMed  Google Scholar 

  4. Collins, A. T., Habib, F. K., Maitland, N. J. & Neal, D. E. Identification and isolation of human prostate epithelial stem cells based on α2β1-integrin expression. J. Cell Sci. 114, 3865–3872 (2001).

    CAS  PubMed  Google Scholar 

  5. Richardson, G. D. et al. CD133, a novel marker for human prostatic epithelial stem cells. J. Cell Sci. 117, 3539–3545 (2004).

    Article  CAS  PubMed  Google Scholar 

  6. Niu, Y. et al. Targeting the stromal androgen receptor in primary prostate tumors at earlier stages. Proc. Natl Acad. Sci. USA 105, 12188–12193 (2008).

    Article  CAS  PubMed  Google Scholar 

  7. Van der Aa, F., Roskams, T., Blyweert, W. & De Ridder, D. Institial cells in the human prostate: a new therapeutic target. Prostate 56, 250–255 (2003).

    Article  PubMed  Google Scholar 

  8. Karbanová, J. et al. The stem cell marker CD133 (Prominin-1) is expressed in various human glandular epithelia. J. Histochem. Cytochem. 56, 977–993 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Grisanzio, C. & Signoretti, S. p63 in prostate biology and pathology. J. Cell. Biochem. 103, 1354–1368 (2008).

    Article  CAS  PubMed  Google Scholar 

  10. Maitland, N. J. & Collins, A. T. Prostate cancer stem cells: a new target for therapy. J. Clin. Oncol. 28, 2862–2870 (2008).

    Article  Google Scholar 

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Authors and Affiliations

  1. Yorkshire Cancer Research Cancer Research Unit, University of York, York, UK

    Anne T. Collins & Norman J. Maitland

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  1. Anne T. Collins
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  2. Norman J. Maitland
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Correspondence to Anne T. Collins.

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Competing interests

N. J. Maitland declared that he is a stockholder/director of Pro-Cure Therapeutics, which owns a patent portfolio relating to potential prostate drug targets. AT Collins and NJ Maitland have declared that they hold patents associated with the Pro-Cure Therapeutics portfolio.

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Collins, A., Maitland, N. Regeneration of interest in the prostate. Nat Rev Urol 6, 184–186 (2009). https://doi.org/10.1038/nrurol.2009.48

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