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Bladder cancer

Brachytherapy-based bladder sparing alternative to cystectomy

A bladder preserving protocol comprising combined external-beam radiotherapy and interstitial brachytherapy for the treatment of bladder cancer has been reported as a viable alternative to cystectomy. However, we have concerns regarding the oncological efficacy of this approach and believe important quality of life issues need to be addressed.

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References

  1. Yafi, F. A., Steinberg, J. R. & Kassouf, W. Contemporary management of muscle-invasive bladder cancer. Int. J. Clin. Oncol. 13, 504–509 (2008).

    Article  PubMed  Google Scholar 

  2. Porter, M. P., Wei, J. T. & Penson, D. F. Quality of life issues in bladder cancer patients following cystectomy and urinary diversion. Urol. Clin. North Am. 32, 207–216 (2005).

    Article  PubMed  Google Scholar 

  3. Rödel, C., Weiss, C. & Sauer, R. Trimodality treatment and selective organ preservation for bladder cancer. J. Clin. Oncol. 24, 5536–5544 (2006).

    Article  PubMed  Google Scholar 

  4. Van Onna, I. E. W. et al. External beam radiation therapy followed by interstitial radiotherapy with iridium-192 for solitary bladder tumors: results of 111 treated patients. Eur. Urol. 56, 113–122 (2009).

    Article  PubMed  Google Scholar 

  5. Herr, H. W. Transurethral resection of muscle-invasive bladder cancer: 10 year outcome. J. Clin. Oncol. 19, 89–93 (2001).

    Article  CAS  PubMed  Google Scholar 

  6. Gofrit, O. N. et al. Adjuvant chemotherapy in lymph node positive bladder cancer. Urol. Oncol. 27, 160–164 (2009).

    Article  CAS  PubMed  Google Scholar 

  7. Stein, J. P. & Skinner, D. G. The role of lymphadenectomy in high-grade invasive bladder cancer. Urol. Clin. North Am. 32, 187–197 (2005).

    Article  PubMed  Google Scholar 

Download references

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Correspondence to Elie Antebi.

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The authors declare no competing financial interests.

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Antebi, E., Manoharan, M. & Soloway, M. Brachytherapy-based bladder sparing alternative to cystectomy. Nat Rev Urol 6, 582–583 (2009). https://doi.org/10.1038/nrurol.2009.212

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