Perspectives

Progress: Neurogenesis in adult primate neocortex: an evaluation of the evidence

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Abstract

Reports of continuous genesis and turnover of neurons in the adult primate association neocortex — the site of the highest cognitive functions — have generated great excitement. Here, I review the available evidence, and question the scientific basis of this claim.

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Acknowledgements

I am grateful to A. Alvarez-Buylla, V. Caviness, F. H. Gage, P. S. Goldman-Rakic, K. Herrup, D. R. Kornack, P. R. Levitt, E. Markakis, J. H. Morrison, E. Mugnaini, R. S. Nowakowski, D. Purves, N. Sestan and D. A. Steindler for their discussion and comments on the manuscript.

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Affiliations

  1. Pasko Rakic is at the Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.pasko.rakic@yale.edu

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