The numerous changes in synaptic physiology and structure that occur in epilepsy are not effectively targeted by the currently available anti-epileptic therapies. Here, Jimenez-Mateos et al. found that miR-134 — a brain-specific microRNA reported to be involved in regulating spine morphology — was upregulated in the brain of patients with epilepsy and in a mouse model of epilepsy. Pharmacological silencing of miR-134 in mice through the use of antagomirs attenuated seizure severity during status epilepticus and reduced cell death and classical hallmarks of epilepsy, such as astrogliosis.
ORIGINAL RESEARCH PAPER
Jimenez-Mateos, E. M. et al. Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects. Nature Med. 10 Jun 2012 (doi:10.1038/nm.2834)
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Lewis, S. Focus on miR-134 for seizures. Nat Rev Neurosci 13, 517 (2012). https://doi.org/10.1038/nrn3296
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DOI: https://doi.org/10.1038/nrn3296