After a pause of nearly 40 years in research into the effects of psychedelic drugs, recent advances in our understanding of the neurobiology of psychedelics, such as lysergic acid diethylamide (LSD), psilocybin and ketamine have led to renewed interest in the clinical potential of psychedelics in the treatment of various psychiatric disorders. Recent behavioural and neuroimaging data show that psychedelics modulate neural circuits that have been implicated in mood and affective disorders, and can reduce the clinical symptoms of these disorders. These findings raise the possibility that research into psychedelics might identify novel therapeutic mechanisms and approaches that are based on glutamate-driven neuroplasticity.
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The authors would like to acknowledge the financial support of the Swiss Neuromatrix Foundation (to F.X.V. and M.K.), and of the Heffter Research Institute (to F.X.V.). The authors thank D. Nichols for critical comments on the manuscript.
The authors declare no competing financial interests.
- Cluster period
A period of time during which cluster headache attacks occur regularly.
Two stereoisomeric molecules that are mirror images of each other and are not superimposable.
- Existentially oriented psychotherapy
A form of therapy that emphasizes the development of a sense of self-direction through choice and of awareness in resolving existential conflicts (such as the inevitability of death, isolation and meaninglessness).
A former term for a category of mental disorders characterized by anxiety and a sense of distress. This category includes disorders now classified as mood disorders, anxiety disorders, dissociative disorders, sexual disorders and somatoform disorders.
- Psychoanalytically oriented psychotherapy
A therapy based on Freudian psychoanalysis in which unconscious conflicts that are thought to cause the patient's symptoms are brought into consciousness to create insight for the resolution of the problems.
In Freudian psychoanalytic theory this term describes a psychological strategy to cope with reality by means of a temporary reversion of the ego to an earlier stage of development.
A drug used to treat amyotrophic lateral sclerosis and that has NMDA (N-methyl-D-aspartate) receptor blocking properties similar to those of ketamine.
- Schedule 1
A legislative category containing controlled drugs that have a high potential for abuse, a lack of accepted safety and no currently accepted medical use in treatments.
- Selective serotonin reuptake inhibitors
A class of compounds typically used as antidepressants.
The motivation to realize all of one's potential.
- Structure–activity relationship
(Often abbreviated to SAR.) This is the relationship between the chemical structure of a molecule and its biological activity.
A phenomenon in psychoanalysis characterized by unconscious redirection of feelings or desires from one person to another.
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Vollenweider, F., Kometer, M. The neurobiology of psychedelic drugs: implications for the treatment of mood disorders. Nat Rev Neurosci 11, 642–651 (2010). https://doi.org/10.1038/nrn2884
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