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Viewing the brain through the master hand of Ramon y Cajal

Abstract

For most neuroscientists, the roots of our discipline stem from Santiago Ramón y Cajal, the Spanish scientist who, during almost half a century of patient work, showed that the nervous system is made up of independent nerve cells. His studies on the anatomical organization of the brain are still a source of inspiration for many of us. His monumental body of work fully justifies that Ramón y Cajal be singled out as the founder of modern neuroscience.

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Figure 1: Frog capillaries showing blood circulation and the passage of leucocytes through the capillary wall.
Figure 2: Chick cerebellum.
Figure 3: Human cerebellum.
Figure 4: Perineuronal astrocytes.
Figure 5: The organization of a folium of the cerebellar cortex.
Figure 6: Some of the connections between cells of the dentate gyrus.
Figure 7: Postscript of a letter sent by Ramón y Cajal to his pupil Fernando de Castro on 19 July 1927.

References

  1. Schwann, T. Mikroskopische Untersuchungen über die Übereinstimmung in der Struktur und dem Wachstum der Tiere und Pflanzen (Sander, Berlin, 1839).

    Google Scholar 

  2. Maestre de San Juan, A. Falta total de los nervios olfactorios con anosmia en un individuo en quien existia una atrofia congénita de los testículos y miembro viril. Siglo Medico 3, 211 (1856).

    Google Scholar 

  3. Ramón y Cajal, S. Estructura de los centros nerviosos de las aves. Rev. Trim. Histol. Normal Patol. 1, 1–10 (1888).

    Google Scholar 

  4. Ramón y Cajal, S. Sobre las fibras nerviosas de la capa molecular del cerebelo. Rev. Trim. Histol. Normal Patol. 1, 33–49 (1888).

    Google Scholar 

  5. Ramón y Cajal, S. Sobre las fibras nerviosas de la capa granulosa del cerebelo. Rev. Trim. Histol. Normal Patol. 1, 107–118 (1889).

    Google Scholar 

  6. Ramón y Cajal, S. The Croonian Lecture. La fine structure des centres nerveux. Proc. R. Soc. Lond. B 55, 444–468 (1894).

    Article  Google Scholar 

  7. Tanzi, E. I fatti e le induzioni dell'odierna istologia del sistema nervoso. Riv. Sper. Fren. Med. Leg. 19, 419–472 (1893).

    Google Scholar 

  8. Ramón y Cajal, S. Un sencillo método de coloración selectiva del retículo protoplásmatico y sus efectos en los diversos órganos nerviosos. Trab. Lab. Invest. Biol. Univ. Madrid 2, 129–221 (1903).

    Google Scholar 

  9. Palade, G. E. & Palay, S. L. Electron microscope observations of interneuronal and neuromuscular synapses. Anat. Rec. 118, 335–336 (1954).

    Google Scholar 

  10. Ramón y Cajal, S. ¿Neuronismo o reticularismo? Las pruebas objetivas de la unidad anatómica de las células nerviosas. Arch. Neurobiol. 13, 1–144 (1933).

    Google Scholar 

  11. Ramón y Cajal, S. La Fotografía de los Colores: Fundamentos Científicos y Reglas Prácticas (Moya, Madrid, 1912).

    Google Scholar 

  12. Ramón y Cajal, S. Textura del Sistema Nervioso del Hombre y de los Vertebrados (Moya, Madrid, 1899).

    Google Scholar 

  13. DeFelipe, J. & Jones, E. G. Santiago Ramón y Cajal and methods in neurohistology. Trends Neurosci. 15, 237–246 (1992).

    CAS  Article  Google Scholar 

  14. Nieto, M. A. Molecular biology of axon guidance. Neuron 17, 1039–1048 (1996).

    CAS  Article  Google Scholar 

  15. Boyde, A. Three-dimensional images of Ramón y Cajal's original preparations, as viewed by confocal microscopy. Trends Neurosci. 15, 246–248 (1992).

    CAS  Article  Google Scholar 

  16. Llinás, R., Baker, R. & Sotelo, C. Electrotonic coupling between neurons in cat inferior olive. J. Neurophysiol. 37, 560–571 (1974).

    Article  Google Scholar 

  17. Llinás, R. R. The contribution of Santiago Ramón y Cajal to functional neuroscience. Nature Rev. Neurosci. 4, 77–80 (2003).

    Article  Google Scholar 

  18. Changeux, J. P. Cajal on neurons, molecules, and consciousness. Ann. NY Acad. Sci. 929, 147–151 (2001).

    CAS  Article  Google Scholar 

  19. Sherrington, C. S. Double (antidromic) conduction in the central nervous system. Proc. Roy. Soc. Lond. B 61, 243–246 (1897).

    Article  Google Scholar 

  20. Ramón y Cajal, S. Significación probable de las células de axon corto. Trab. Lab. Invest. Biol. Univ. Madrid 1, 151–157 (1901).

    Google Scholar 

  21. Piccolino, M. Cajal and the retina: a 100-year retrospective. Trends Neurosci. 11, 521–525 (1988).

    CAS  Article  Google Scholar 

  22. Ramón y Cajal, S. Les problèmes histophysiologiques de la rétine. XIV Concilium. Ophthalmologicum Hispaniae 11, 11–19 (1933).

    Google Scholar 

  23. Gallego, A. Reflejo de la obra de Cajal en la neurofisiología moderna. An. Ins. Farm. Esp. 11–12, 25–50 (1963).

  24. Ramón y Cajal, S. Recuerdos de Mi Vida: Historia de Mi Labor Científica 3rd edn (Juan Pueyo, Madrid, 1923).

    Google Scholar 

  25. Droz, B. in The Nervous System (ed. Tower, D. B.) 115–127 (Raven, New York, 1975).

    Google Scholar 

  26. Ramón y Cajal, S. Cajal's Degeneration & Regeneration of the Nervous System (eds DeFelipe, J. & Jones, E. G) (Oxford Univ. Press, New York, 1991).

    Book  Google Scholar 

  27. Sotelo, C. & Alvarado-Mallart, R. M. The reconstruction of cerebellar circuits. Trends Neurosci. 14, 350–355 (1991).

    CAS  Article  Google Scholar 

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Acknowledgements

I thank J. Lerma and H. Korn for useful discussions.

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DATABASES

OMIM

Kallmann syndrome

FURTHER INFORMATION

Encyclopedia of Life Sciences

Ramón y Cajal, Santiago

MIT Encyclopedia of Cognitive Sciences

Cajal, Santiago Ramón y

Golgi, Camillo

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Sotelo, C. Viewing the brain through the master hand of Ramon y Cajal. Nat Rev Neurosci 4, 71–77 (2003). https://doi.org/10.1038/nrn1010

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