Glial migration

Tyrolean traversing through the brain

Here, live-imaging of cortical slices from mice at embryonic day 16 (E16) and E18 revealed that OPCs 'crawl' along blood vessels. WNT-activated OPCs expressed the chemokine receptor CXCR4, which binds endothelial stromal cell-derived factor 1 (SDF1), and application of an antagonist of the CXCR4–SDF1 interaction prevented OPC clustering on blood vessels of mice with upregulated WNT signalling. Thus, WNT signalling promotes OPC–endothelial cell attachment during migration.

References

  1. 1

    Tsai, H.-H. et al. Oligodendrocyte precursors migrate along vasculature in the developing nervous system. Science 351, 379–384 (2016)

    CAS  Article  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bray, N. Tyrolean traversing through the brain. Nat Rev Neurosci 17, 138 (2016). https://doi.org/10.1038/nrn.2016.15

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing