Glial migration

Tyrolean traversing through the brain

Here, live-imaging of cortical slices from mice at embryonic day 16 (E16) and E18 revealed that OPCs 'crawl' along blood vessels. WNT-activated OPCs expressed the chemokine receptor CXCR4, which binds endothelial stromal cell-derived factor 1 (SDF1), and application of an antagonist of the CXCR4–SDF1 interaction prevented OPC clustering on blood vessels of mice with upregulated WNT signalling. Thus, WNT signalling promotes OPC–endothelial cell attachment during migration.


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Bray, N. Tyrolean traversing through the brain. Nat Rev Neurosci 17, 138 (2016).

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