Abstract
This month's Genome Watch delves deep into the human gastrointestinal tract, describing the genome sequences of two major constituents of the gut microflora: Lactobacillus acidophilus, which is both commercially and medically important for its role as a probiotic, and Bacteroides fragilis, which, although a major constituent of the natural gut flora, is also an opportunistic pathogen that can cause an array of infections.
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References
Altermann, E. et al. Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM. Proc. Natl Acad. Sci. USA 102, 3906–3912 (2005).
Kuwara, T. et al. Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation. Proc. Natl Acad. Sci. USA 101, 14919–14924 (2004).
Cerdeño-Tárraga, A. et al. Extensive DNA inversions in the B. fragilis genome control variable gene expression. Science 307, 1463–1465 (2005).
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DATABASES
Entrez
Lactobacillus acidophilus strain NCFM
Bacteroides fragilis strain YCH46
Bacteroides fragilis strain NCTC 9343
FURTHER INFORMATION
Kitasato University Microbial Genome Projects
Lactobacillus acidophilus genome project
Lactic acid bacteria genome consortium
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Cerdeño-Tárraga, A., Claesson, M., Sebaihia, M. et al. GI genomes. Nat Rev Microbiol 3, 368–369 (2005). https://doi.org/10.1038/nrmicro1153
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DOI: https://doi.org/10.1038/nrmicro1153
