Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Understanding drug resistance will improve the treatment of bacterial infections

An improved understanding of the origins and spread of drug-resistant bacteria, as well as the identification of novel antimicrobial compounds and new drug combinations, will facilitate the development of better dosing regimens and novel strategies to manage drug resistance and prevent the dissemination of resistant bacteria.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout


  1. Bevan, E. R., Jones, A. M. & Hawkey, P. M. Global epidemiology of CTX-M β-lactamases: temporal and geographical shifts in genotype. J. Antimicrob.Chemother. 72, 2145–2155 (2017).

    Article  CAS  Google Scholar 

  2. Basarab, G. S. et al. Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases. Sci. Rep. 5, 11827 (2015).

    Article  CAS  Google Scholar 

  3. Fisher, J. F. & Mobashery, S. Endless resistance. Endless antibiotics? Medchemcomm 7, 37–49 (2016).

    Article  CAS  Google Scholar 

  4. Richter, M. F. et al. Predictive compound accumulation rules yield a broad-spectrum antibiotic. Nature 545, 299–304 (2017).

    Article  CAS  Google Scholar 

  5. Llewelyn M. J. et al. The antibiotic course has had its day. BMJ 358, j3418 (2017).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Laura J. V. Piddock.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Related links

Related links


European Union Joint Programming Initiative on Antimicrobial Resistance


Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Piddock, L. Understanding drug resistance will improve the treatment of bacterial infections. Nat Rev Microbiol 15, 639–640 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing