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Epsins: adaptors in endocytosis?

Nature Reviews Molecular Cell Biology volume 3, pages 971–977 (2002)Cite this article

Abstract

Endocytic adaptor proteins select specific cargo for internalization by endocytosis through clathrin-coated pits or vesicles. Recent studies indicate that epsins might also be classified as adaptors.

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Figure 1: Endocytic adaptor proteins.
Figure 2: Epsin domain structure.
Figure 3: Functions of ubiquitin-interacting motifs.

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Acknowledgements

I apologize to those whose work could not be cited because of space restrictions. I would like to thank the members of my laboratory for stimulating discussions, and for critical reading of the manuscript I thank Pietro De Camilli, Kyle Cunningham, Ruben Claudio Aguilar, Hadiya Watson and J. Michael McCaffery. My laboratory is generously supported by grants from the National Institutes of Health, the Burroughs Wellcome Fund and the Human Frontiers Scientific Program.

Author information

Authors and Affiliations

  1. the Department of Biology, Johns Hopkins University, 3400 North Charles Street, Mudd Hall, Baltimore, 21218, Maryland, USA

    Beverly Wendland

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  1. Beverly Wendland
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Related links

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DATABASES

InterPro

EH

ENTH

UBA

UIM

VHS

LocusLink

AP2

<i>Saccharomyces</i> Genome Database

Apl3

Ede1

Ent1

Ent2

Pan1

Swiss-Prot

AP180

β-arrestin

epsin 1

Eps15

Fat facets

GFP

intersectin

Liquid facets

POB1

Ral

RalBP1

FURTHER INFORMATION

Beverly Wendland's laboratory

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Wendland, B. Epsins: adaptors in endocytosis?. Nat Rev Mol Cell Biol 3, 971–977 (2002). https://doi.org/10.1038/nrm970

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