There is much interest in defining the secretory transport vesicles that sort cargo at the Golgi for trafficking to different regions of the plasma membrane. Wakana et al. have found a new class of transport carrier that forms in the trans-Golgi network (TGN) and then targets the cell surface in HeLa cells. These carriers, which they term CARTS (carriers of the TGN to the cell surface), require protein kinase D for their biogenesis and myosin II for their movement. They carry a specific set of cargo proteins and are distinct from previously characterized carriers that transport large cargo such as the VSV-G glycoprotein. Characterization of CARTS should therefore provide new understanding of cargo sorting for transport to the cell surface from the Golgi.
ORIGINAL RESEARCH PAPER
Wakana, Y. et al. A new class of carriers that transport selective cargo from the trans Golgi network to the cell surface. EMBO J. 21 Aug 2012 (doi:10.1038/emboj.2012.235)
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Schuldt, A. A new transport carrier. Nat Rev Mol Cell Biol 13, 602 (2012). https://doi.org/10.1038/nrm3447
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DOI: https://doi.org/10.1038/nrm3447