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Organelle dynamics

Stopping mitochondria in their tracks

Nature Reviews Molecular Cell Biology volume 13, pages 4–5 (2012)Cite this article

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PINK1 immunoprecipitates had previously been shown to contain the kinesin adaptors MIRO and Milton, which form a complex with Kinesin-1 heavy chain (KHC) to mediate mitochondrial transport in axons. Thus, the authors first determined whether PINK1 and parkin influence mitochondrial transport in rat and Drosophila melanogaster axons. PINK1 or parkin overexpression inhibited the bidirectional movement of mitochondria in both systems, and in both cases the ability of PINK1 to arrest movement was dependent on parkin. Thus, PINK1 appears to work upstream of parkin to arrest mitochondrial movement in an evolutionarily conserved manner.

PINK1 phosphorylates... MIRO... this triggers the parkin-dependent degradation of MIRO to halt the movement of mitochondria

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References

ORIGINAL RESEARCH PAPER

  1. Wang, X. et al. PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell 147, 893–906 (2011) Article

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FURTHER READING

  1. Youle, R. J. & Narendra, D. P. Mechanisms of mitophagy. Nature Rev. Mol. Cell Biol. 12, 9–14 (2011)

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Authors
  1. Katharine H. Wrighton
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Wrighton, K. Stopping mitochondria in their tracks. Nat Rev Mol Cell Biol 13, 4–5 (2012). https://doi.org/10.1038/nrm3251

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