Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Cytoskeleton

Midzone microtubule management

Nature Reviews Molecular Cell Biology volume 11, pages 602–603 (2010)Cite this article

Subjects

PRC1 belongs to the conserved MAP65 family that cross-link antiparallel microtubules, and is essential for central spindle formation in eukaryotes. Subramanian et al. set out to characterize the structural basis of human PRC1 function and show that microtubule binding requires both the central region of PRC1 and a cluster of basic residues in its disordered carboxy-terminal region. Using X-ray crystallography, they show that PRC1's central microtubule-binding domain adopts a spectrin fold. This is surprising as spectrin domains are normally found in proteins that bind the actin cytoskeleton.

“PRC1 has an intrinsic ability to bind selectively to antiparallel microtubules in the spindle and to control midzone organization by recruiting a kinesin-4 motor.”

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPERS

  1. Subramanian, R. et al. Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein. Cell 142, 433–443 (2010)

    Article  CAS  Google Scholar 

  2. Bieling, P., Telley, I. A. & Surrey, T. A minimal midzone protein module controls formation and length of antiparallel microtubule overlaps. Cell 142, 420–432 (2010)

    Article  CAS  Google Scholar 

Download references

Authors
  1. Alison Schuldt
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schuldt, A. Midzone microtubule management. Nat Rev Mol Cell Biol 11, 602–603 (2010). https://doi.org/10.1038/nrm2965

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrm2965

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing