Abstract
The maintenance of organ homeostasis and the control of an appropriate response to environmental alterations require the intimate coordination of cellular functions and tissue organization. An important component of this coordination could be provided by proteins that can have distinct but linked functions on both sides of the plasma membrane. We present a model that proposes that unconventional secretion provides a mechanism through which single proteins can integrate complex tissue functions.
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Acknowledgements
Our work was supported by grants from the Office of Biological and Environmental Research of the Department of Energy (DE-AC03-76SF00098 and a Distinguished Fellow Award; to M.J.B.); the National Cancer Institute CA64786 (to M.J.B.), CA57621 (to M.J.B. and Z. Werb), CA122086 (to D.C.R.), CA128660 (to C. M. Nelson and D.C.R.) and the Breast Cancer Research Program of the Department of Defense (an Innovator Award; to M.J.B.).
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Radisky, D., Stallings-Mann, M., Hirai, Y. et al. Single proteins might have dual but related functions in intracellular and extracellular microenvironments. Nat Rev Mol Cell Biol 10, 228–234 (2009). https://doi.org/10.1038/nrm2633
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DOI: https://doi.org/10.1038/nrm2633
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