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Helping Wingless take flight: how WNT proteins are secreted

Nature Reviews Molecular Cell Biology volume 8, pages 331–336 (2007)Cite this article

Abstract

How functional WNT proteins are made and how their secretion is regulated is becoming a focal point for the WNT-signalling field. Recently, lipoprotein particles, WNT lipid modifications, the conserved transmembrane protein Wntless (WLS; also known as EVI and SRT) and the retromer complex have been implicated in WNT secretion. Our aim is to synthesize ideas from these new findings for the mechanisms that underlie WNT secretion.

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Figure 1: Overview of the localization and trafficking of WNT proteins.
Figure 2: Hypothetical routes for WNT exocytosis.
Figure 3: WNT exocytosis requires endocytosis.

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  1. George Hausmann, Carla Bänziger and Konrad Basler are at the Institut für Molekularbiologie, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland,

    George Hausmann, Carla Bänziger & Konrad Basler

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Hausmann, G., Bänziger, C. & Basler, K. Helping Wingless take flight: how WNT proteins are secreted. Nat Rev Mol Cell Biol 8, 331–336 (2007). https://doi.org/10.1038/nrm2141

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