Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Signal transduction

Understanding NEMO

Nature Reviews Molecular Cell Biology volume 7, pages 384–385 (2006)Cite this article

...these two important papers have revealed ... the biochemical mechanism that underlies the essential signalling function of NEMO in IKK activation.

Despite the important role of IKK in NF-κB activation, exactly how TNFR1 signalling results in the NEMO-dependent activation of NF-κB is unclear. Furthermore, NEMO is essential for IKK activation, but how it regulates IKK is unknown. However, two papers now provide insights — one by Ashwell and colleagues in Nature Cell Biology and another by Chen and co-workers in Molecular Cell.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPERS

  1. Wu, C.-J. et al. Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation. Nature Cell Biol. 8, 398–406 (2006)

    Article  CAS  Google Scholar 

  2. Ea, C.-K. et al. Activation of IKK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol. Cell 22, 245–257 (2006)

    Article  CAS  Google Scholar 

Download references

Authors
  1. Rachel Smallridge
    View author publications

    You can also search for this author in PubMed Google Scholar

Related links

Related links

WEB SITES

Jonathan Ashwell's laboratory

Zhijian Chen's laboratory

Rights and permissions

Reprints and permissions

About this article

Cite this article

Smallridge, R. Understanding NEMO. Nat Rev Mol Cell Biol 7, 384–385 (2006). https://doi.org/10.1038/nrm1944

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrm1944

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing