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The calcium-signalling saga: tap water and protein crystals

Nature Reviews Molecular Cell Biology volume 4, pages 326–332 (2003)Cite this article

Abstract

Of the approximately 1,400 grams of calcium that are in the human body, less than 10 grams manage to escape being trapped in the skeleton and teeth. These few grams might be an insignificant quantity, but they are extraordinarily significant qualitatively. They circulate in the blood and extracellular spaces, and penetrate cells to regulate their most important activities.

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Figure 1: Sydney Ringer.
Figure 2: The control of cellular Ca2+.
Figure 3: The three-dimensional structure of parvalbumin.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Padova, Padova, 35121, Italy

    Ernesto Carafoli

  2. Venetian Institute of Molecular Medicine (VIMM), Padova, 35129, Italy

    Ernesto Carafoli

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  1. Ernesto Carafoli
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Related links

Related links

DATABASES

InterPro

C2

EF-hand

LocusLink

calbindin

calcineurin

calmodulin kinase II

calsequestrin

troponin c

Swiss-Prot

annexin II

annexin V

Calmodulin kinase IV

DREAM

gelsolin

LTRPC2

phospholamban

PMCA1

PMCA2

PMCA3

PMCA4

recoverin

RYR1

RYR2

SERCA1

SERCA2

FURTHER INFORMATION

Ernesto Carafoli's laboratory

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Carafoli, E. The calcium-signalling saga: tap water and protein crystals. Nat Rev Mol Cell Biol 4, 326–332 (2003). https://doi.org/10.1038/nrm1073

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