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Progress in mitochondrial replacement therapies

Abstract

Mitochondrial DNA is maternally inherited, and pathogenic mutations cause a range of life-limiting conditions. Recent studies indicate that transmission of pathogenic mutations may be prevented by reproductive technologies designed to replace the mitochondria in eggs from affected women.

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Acknowledgements

Work in the authors' laboratories is funded by grants from The Wellcome Centre for Mitochondrial Research, Medical Research Council, EU Horizon 2020 and the UK NIHR Biomedical Research Centre awarded to Newcastle upon Tyne NHS Trust.

Author information

Affiliations

  1. Wellcome Centre for Mitochondrial Research, Institute of Genetic Medicine and Institute of Neurosciences, Newcastle University, Newcastle upon Tyne, UK

    • Mary Herbert
    •  & Doug Turnbull

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Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Mary Herbert or Doug Turnbull.