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Charting the unknown epitranscriptome

Nature Reviews Molecular Cell Biology volume 18, pages 339340 (2017) | Download Citation

Abstract

RNA modifications can alter RNA structure–function relationships and various cellular processes. However, the genomic distribution and biological roles of most RNA modifications remain uncharacterized. Here, we propose using phage display antibody technology and direct sequencing through nanopores to facilitate systematic interrogation of the distribution, location and dynamics of RNA modifications.

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Author information

Affiliations

  1. Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.

    • Eva Maria Novoa
    •  & John S. Mattick
  2. University of New South Wales, Sydney, NSW 2052, Australia.

    • Eva Maria Novoa
    •  & John S. Mattick
  3. Weill Cornell Medicine, New York, NY 10021, USA.

    • Christopher E. Mason

Authors

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Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Eva Maria Novoa or Christopher E. Mason or John S. Mattick.

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Published

DOI

https://doi.org/10.1038/nrm.2017.49

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