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Non-coding RNA

LINP1 joins ends with triple-negative effect

Nature Reviews Molecular Cell Biology volume 17, pages 330–331 (2016)Cite this article

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Breast cancers that lack HER2 (also known as ERBB2) gene amplification and express neither oestrogen receptor nor progesterone receptor are termed triple-negative breast cancers (TNBC). This cancer subtype is associated with epidermal growth factor receptor (EGFR) gene amplification and TP53 mutations, and responds poorly to therapy. To identify possible mechanisms underlying the resistance of TNBC to treatment, the authors performed an RNA interference screen for lncRNAs that protect TNBC cells from DNA double-strand break (DSB)-induced apoptosis. One validated screen-hit was a lncRNA that is highly expressed in TNBC, in TNBC cell lines (MDA-MB-231 and MDA-MB-468) and in triple-negative immortalized mammary cells (MCF10A), but is undetectable in oestrogen receptor-positive MCF7 cells.

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References

  1. Zhang, Y. et al. Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer. Nat. Struct. Mol. Biol. http://dx.doi.org/10.1038/nsmb.3211 (2016)

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  1. Eytan Zlotorynski
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Zlotorynski, E. LINP1 joins ends with triple-negative effect. Nat Rev Mol Cell Biol 17, 330–331 (2016). https://doi.org/10.1038/nrm.2016.60

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  • DOI: https://doi.org/10.1038/nrm.2016.60

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