Inter-individual differences in DNA methylation are thought to contribute to disease risk, but what influences these differences in methylation? This paper provides valuable insight by presenting the genome-wide methylation profiles of neonatal mono- and dizygotic twins. The differences they detect within twin pairs highlight the importance of intra-uterine environment and/or stochastic effects in early development.
ORIGINAL RESEARCH PAPER
Gordon, L. et al. Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence. Genome Res. 22, 1395–1406 (2012)
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Muers, M. Variation in methylomes of neonatal twins. Nat Rev Genet 13, 598 (2012). https://doi.org/10.1038/nrg3326
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DOI: https://doi.org/10.1038/nrg3326