This paper presents a genetic interaction map of Schizosaccharomyces pombe and compares it with genetic interactions previously mapped in Saccharomyces cerevisiae. The authors found widespread conservation of interactions, but a subset of orthologous complexes seems to have different functions. They term this evolution of different partners or functional relationships 'repurposing' and link repurposing to important cellular processes, such as mitosis.
ORIGINAL RESEARCH PAPER
Frost, A. et al. Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Cell 149, 1339–1352 (2012)
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Muers, M. Orthologues undergo functional repurposing. Nat Rev Genet 13, 451 (2012). https://doi.org/10.1038/nrg3276
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DOI: https://doi.org/10.1038/nrg3276