During repair of an I-SceI endonuclease-triggered double-stranded DNA break (DSB) in Arabidopsis thaliana, Wei et al. detected small RNAs corresponding to regions surrounding the DSB. The production of these small RNAs and the repair efficiency were attenuated in plants that were deficient for components of the RNAi machinery, suggesting an active role for small RNA processing in the repair; similar results were obtained in human cells. The precise molecular details and relevance for non-I-SceI DNA damage remain to be determined.
ORIGINAL RESEARCH PAPER
Wei, W. et al. A role for small RNAs in DNA double-strand break repair. Cell 149, 101–112 (2012)
Rights and permissions
About this article
Cite this article
Burgess, D. Small RNAs in DNA repair. Nat Rev Genet 13, 299 (2012). https://doi.org/10.1038/nrg3237
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrg3237