Polycomb group proteins are developmental gene expression regulators that localize to regions of the nucleus called Polycomb bodies. The authors monitored the dynamics at Polycomb bodies during development in Drosophila melanogaster. They showed that Polycomb proteins are gradually recruited to these compartments during embryogenesis. Furthermore, two types of chromosomal movement at Polycomb bodies — a fast, highly constrained motion and a slower, long-range motion that was indicative of chromosome territory movement — decreased through development, suggesting a role for this movement in gene regulation.
ORIGINAL RESEARCH PAPER
Cheutin, T. & Cavalli, G. Progressive Polycomb assembly on H3K27me3 compartments generates Polycomb bodies with developmentally regulated motion. PLoS Genet. 8, e1002465 (2012)Article
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Chromosome dynamics in Polycomb regulation. Nat Rev Genet 13, 149 (2012). https://doi.org/10.1038/nrg3195
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DOI: https://doi.org/10.1038/nrg3195