A flood of comparative genomic data is resulting in the identification of human lineage-specific (HLS) sequences. As apes are our closest evolutionary relatives, transgenic introduction of HLS sequences into these species has the greatest potential to produce 'humanized' phenotypes and also to illuminate the functions of these sequences. We argue that such transgenic apes would also be more likely than other species to experience harm from such research, which renders such studies ethically unacceptable in apes and justifies regulatory barriers between these species and other non-human primates for HLS transgenic research.
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The authors acknowledge the assistance of C.J. McCormick, M. O'Bleness, L. Dumas, J. Dang, J. Keeney and M. Douse for critical reading and preparation of the manuscript. J.M.S. is supported by National Institutes of Health (NIH) grants R01-MH081203 and RO1-AA11853. M.E.C. is supported by NIH grants 5P60DA011015 and RO1-DA029258. E.T.J. is supported by NIH grant P50-HG03390.
The authors declare no competing financial interests.
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Coors, M., Glover, J., Juengst, E. et al. The ethics of using transgenic non-human primates to study what makes us human. Nat Rev Genet 11, 658–662 (2010). https://doi.org/10.1038/nrg2864
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