Whether you are leafing through the print copy of this issue or clicking your way through it online you will probably have noticed something different. January sees the launch of the new print design of Nature Reviews Genetics, which follows on from the online redesign that we introduced last month. All our standard features, such as a glossary and a list of the relevant online resources, are still there on our web site, but we hope that you will find the site more attractive and easier to navigate. There are a few specific features to look out for. To make our publications even more up-to-date, articles will be posted online every week ahead of print publication. And short summaries of each article will be visible on the homepage itself, to help you decide whether you would like to click through to the full-length version. Any current or archived special projects — such as themed issues, posters or article series — are now prominently displayed on the homepage, and our figures can now be downloaded as PowerPoint files for easier use in teaching and scientific presentations.

This month, subscribers to Nature Reviews Genetics also receive a poster on 'RNA interference and its applications', which was produced with support from Sigma-Aldrich. In this poster, René Ketting and Ronald Plasterk describe the mechanism of RNAi, how this stable and robust knockdown technique is being applied in the laboratory, and its development for clinical and agricultural applications. The poster can also be found on the web site of the Nature Reviews article collection on 'RNA interference' (at http://www.nature.com/nrg/poster/rnai/index.html).