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Sickle cell disease

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This PrimeView highlights the complex pathophysiological mechanisms of sickle cell disease (SCD), which stem from the polymerization of sickle haemoglobin (HbS), a mutant haemoglobin variant. Erythrocytes containing HbS polymers assume the crescent shape that gives SCD its name.

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Sickle cell disease. Nat Rev Dis Primers 4, 18011 (2018).

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