This PrimeView highlights the mechanisms of α1-antitrypsin deficiency (A1ATD), an inherited disorder caused by mutations in SERPINA1. A1ATD leads to liver and lung disease and can be associated with substantial morbidity and increased mortality.
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α1-Antitrypsin deficiency. Nat Rev Dis Primers 2, 16052 (2016). https://doi.org/10.1038/nrdp.2016.52