Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

α1-Antitrypsin deficiency

This PrimeView highlights the mechanisms of α1-antitrypsin deficiency (A1ATD), an inherited disorder caused by mutations in SERPINA1. A1ATD leads to liver and lung disease and can be associated with substantial morbidity and increased mortality.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

α1-Antitrypsin deficiency. Nat Rev Dis Primers 2, 16052 (2016).

Download citation

  • Published:

  • DOI:


Quick links