Nat. Rev. Dis. Primers article number: 15059; doi:10.1038/nrdp.2015.59; published online 15 October 2015

In the version of the PrimeView published, a typographical error has now been corrected. The statement now reads: Aβ is produced throughout an individual's lifetime; impaired clearance of Aβ and/or conformational changes are central to the development of Alzheimer's disease.