Malaria

Complete protection with AMA1–RON2 complex?

The apical membrane antigen 1 (AMA1), a crucial protein for the invasion of Plasmodium merozoites into red blood cells, is a leading malaria vaccine candidate, but has shown little efficacy in clinical trials so far. Here, the authors show that vaccination with a complex of AMA1 and rhoptry neck protein 2 (RON2) can induce antibody-mediated complete protection against a lethal Plasmodium yoelii challenge in mice. It is likely that the protein complex mimics the functional form of the proteins more closely, thereby inducing more potent protective antibodies.

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    Srinivasan, P. et al. Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria. Proc. Natl Acad. Sci. USA 111, 10311–10316 (2014)

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Flemming, A. Complete protection with AMA1–RON2 complex?. Nat Rev Drug Discov 13, 654 (2014). https://doi.org/10.1038/nrd4429

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