Complete protection with AMA1–RON2 complex?

The apical membrane antigen 1 (AMA1), a crucial protein for the invasion of Plasmodium merozoites into red blood cells, is a leading malaria vaccine candidate, but has shown little efficacy in clinical trials so far. Here, the authors show that vaccination with a complex of AMA1 and rhoptry neck protein 2 (RON2) can induce antibody-mediated complete protection against a lethal Plasmodium yoelii challenge in mice. It is likely that the protein complex mimics the functional form of the proteins more closely, thereby inducing more potent protective antibodies.


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Flemming, A. Complete protection with AMA1–RON2 complex?. Nat Rev Drug Discov 13, 654 (2014).

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