Notch signalling, which was identified a century ago, is crucial for the development and homeostasis of most tissues. In their Review on page 357, Andersson and Lendahl highlight disorders in which Notch signalling is dysregulated — such as T cell leukaemia — and discuss how the Notch pathway could be therapeutically targeted.
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Recent patents related to Notch signalling. Nat Rev Drug Discov 13, 327 (2014). https://doi.org/10.1038/nrd4329
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DOI: https://doi.org/10.1038/nrd4329