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Drugging cancer genomes


A recent landmark analysis compared genome-wide mutations and associated 'omics' features for 3,281 tumours across 12 human cancer types. There is a clear need for objective target assessment and prioritization by the drug discovery community to make the best use of such vast amounts of data.

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Author information



Corresponding authors

Correspondence to Paul Workman or Bissan Al-Lazikani.

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Competing interests

The authors work at The Institute of Cancer Research, London, UK, which has a commercial interest in the discovery and development of anticancer drugs.

Supplementary information

Supplementary information S1 (box)

Objective analysis of cancer genes (PDF 2031 kb)

Related links

Related links


The Cancer Genome Atlas

International Cancer Genome Consortium

Focus on TCGA Pan-Cancer Analysis

canSAR knowledgebase

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Workman, P., Al-Lazikani, B. Drugging cancer genomes. Nat Rev Drug Discov 12, 889–890 (2013).

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