Toll-like receptor agonists have hit another setback with the Phase II failure of Idera's IMO-2055, but these immunotherapies may still make a comeback if appropriate combinations with vaccine antigens or anticancer drugs can be identified.
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Guha, M. Anticancer TLR agonists on the ropes. Nat Rev Drug Discov 11, 503–505 (2012). https://doi.org/10.1038/nrd3775
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DOI: https://doi.org/10.1038/nrd3775
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