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Crizotinib

Abstract

In August 2011 crizotinib (Xalkori; Pfizer), a small-molecule kinase inhibitor, was approved by the US Food and Drug Administration (FDA) for the treatment of patients with locally advanced or metastatic non-small-cell lung cancer that is anaplastic lymphoma kinase-positive, as detected by an FDA-approved test.

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Figure 1: Crizotinib.

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Correspondence to Alice T. Shaw, Uma Yasothan or Peter Kirkpatrick.

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Competing interests

Alice T. Shaw has been a consultant for Pfizer, Chugai and Ariad.

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Shaw, A., Yasothan, U. & Kirkpatrick, P. Crizotinib. Nat Rev Drug Discov 10, 897–898 (2011). https://doi.org/10.1038/nrd3600

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