The structure of suramin on page 844 is incorrect; the correct structure is shown below:
The following paragraph and associated reference were mistakenly omitted from the discussion of the role of sirtuins in cancer on page 850:
“In a recent effort to identify activators of p53 in a mammalian cell-based screen, a reporter construct was placed under the regulation of a p53 target promoter, and active compounds that increased reporter activity were selected from the library screen. This strategy led to the identification of a series of compounds called tenovins1.”
References
Lain, S. et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13, 454–463 (2008).
Additional information
The online version of the original article can be found at 10.1038/nrd2665
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Lavu, S., Boss, O., Elliott, P. et al. Erratum: Sirtuins — novel therapeutic targets to treat age-associated diseases. Nat Rev Drug Discov 8, 516 (2009). https://doi.org/10.1038/nrd2920-c1
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DOI: https://doi.org/10.1038/nrd2920-c1
