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Tumour molecular profiling for deciding therapy—the French initiative

Nature Reviews Clinical Oncology volume 9, pages 479–486 (2012)Cite this article

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Abstract

The use of tumour molecular profiles for therapeutic decision making requires that molecular diagnostics be introduced into routine clinical practice. To this end, the French National Cancer Institute and French Ministry of Health have set up a national network of 28 regional molecular genetics centres. These facilities perform selected molecular tests, free of charge, for all patients in their region, regardless of the institution where they are treated. A specific programme has also been implemented to anticipate the launch of new targeted treatments and reduce time-to-access to new drugs and experimental therapies. In 2011, 55,000 patients with cancer in France benefited from molecular predictive tests. The French nationwide initiative for tumour molecular profiling is a tool to fight inequalities in access to molecular testing and targeted therapy, and demonstrates that molecular stratification of tumours for therapeutic decisions is a cost-effective strategy that can be successfully integrated into the health-care system.

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Figure 1: The location of molecular genetics centres in France.
Figure 2: Predictive molecular testing activity in France 2007–2011.

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Acknowledgements

We wish to thank M. P. Gaub, J. P. Ghnassia, J. P. Merlio, A. Tchirkov, M. L. Kottler, F. Piard, J. F. Abgrall, T. Fest, J. C. Pagès, C. Clavel, C. Mougin, J. C. Sabourin, J. M. Bidart, O. Delattre, I. Bièche, M. Marty, P. Laurent-Puig, T. Molina, T. Maudelonde, F. Labrousse, J. Feuillard, P. Jonveaux, E. Delabesse, N. Porchet, H. Avet-Loiseau, M. Denis, A. Morel, P. Reynier, A. Turhan, L. Karayan-Tapon, F. Pedeutour, J. Gabert, J. Y. Scoazec, D. Leroux, L. Campos and the staff of the 28 molecular genetics centres, J. Blin, E. Lonchamp and B. Mourlat of INCa, the previous president of INCa, D. Maraninchi, and the current president of INCa, A. Buzyn.

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Authors and Affiliations

  1. Direction de la Recherche et de l'Innovation, Institut National du Cancer, 52 Avenue André Morizet, Boulogne Billancourt 92153, France,

    Frédérique Nowak & Fabien Calvo

  2. Department of Medicine, Institut Gustave-Roussy, 114 rue Edouard Vaillant, Villejuif, 94805, France

    Jean-Charles Soria

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  1. Frédérique Nowak
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All authors researched data for the article, made a considerable contribution to the discussion of the content, wrote the manuscript and edited and revised the article before submission.

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Correspondence to Fabien Calvo.

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Nowak, F., Soria, JC. & Calvo, F. Tumour molecular profiling for deciding therapy—the French initiative. Nat Rev Clin Oncol 9, 479–486 (2012). https://doi.org/10.1038/nrclinonc.2012.42

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