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Medical oncology

Optimizing chemotherapy and radiotherapy for anaplastic glioma

The optimum approach for the treatment of rare anaplastic gliomas following surgical resection is uncertain. A recent study has now provided a greater understanding of the heterogeneous tumor biology of these tumors and has emphasized the prognostic importance of chromosome 1p19q deletion, IDH mutation and MGMT promoter methylation. The importance of radiotherapy and chemotherapy for treating these heterogeneous tumors is being elucidated for subgroups of patients.

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Correspondence to Andrew B. Lassman.

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Competing interests

P. G. Morris has received honoraria from the following companies: Eisai, Genomic Health, Pfizer, Haymarket Media Group, Bristol-Myers Squibb, Genentech, Novartis and Centocor Ortho Biotech. A. B. Lassman acts as a consultant for, and has received honoraria and research support from, Merck & Co. He has received research support from Keryx Biopharmaceuticals, Sigma Tau Pharmaceuticals and Genentech and acts as a consultant for Genentech, Eisai, ImClone and Cephalon.

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Morris, P., Lassman, A. Optimizing chemotherapy and radiotherapy for anaplastic glioma. Nat Rev Clin Oncol 7, 428–430 (2010).

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