A spectrum of common illnesses that constitute risk factors for cardiovascular diseases is associated with both cognitive impairment and high population mortality. Many clinical trials are focused on the prevention of cardiovascular mortality, but cognitive impairment should now be regarded as a similarly important outcome.
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References
O'Donnell, M. et al. Cognitive impairment and risk of cardiovascular events and mortality. Eur. Heart J. http://dx.doi.org/10.1093/eurheartj/ehs053.
Hebert, L. E., Scherr, P. A., Bienias, J. L., Bennett, D. A. & Evans, D. A. State-specific projections through 2025 of Alzheimer disease prevalence. Neurology 62, 1645 (2004).
Seshadri, S. et al. The lifetime risk of stroke: estimates from the Framingham Study. Stroke 37, 345–350 (2006).
Schneider, J. A., Arvanitakis, Z., Bang, W. & Bennett, D. A. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 69, 2197–2049 (2007).
Decarli, C. et al. Measures of brain morphology and infarction in the Framingham Heart Study: establishing what is normal. Neurobiol. Aging 26, 491–510 (2005).
Debette, S. et al. Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline. Neurology 77, 461–468 (2011).
Debette, S. et al. Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study. Stroke 41, 600–606 (2010).
Folstein, M. F., Folstein, S. E. & McHugh, P. R. “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12, 189–198 (1975).
DeCarli, C. et al. Predictors of brain morphology for the men of the NHLBI twin study. Stroke 30, 529–536 (1999).
Whitmer, R. A., Sidney, S., Selby, J., Johnston, S. C. & Yaffe, K. Midlife cardiovascular risk factors and risk of dementia in late life. Neurology 64, 277–281 (2005).
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DeCarli, C. Assessing the brain as an end-organ of vascular disease. Nat Rev Cardiol 9, 435–436 (2012). https://doi.org/10.1038/nrcardio.2012.92
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DOI: https://doi.org/10.1038/nrcardio.2012.92
