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Single-molecule light absorption

It has long been thought that the detection of individual molecules in ambient conditions via their absorption signature was out of reach. Now, three independent research groups have developed three different methods that allow such a feat.

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Figure 1: Three different methods that allow detection of light absorption by single molecules (yellow dot) in the focus of a light beam (blue).


  1. Moerner, W. E. & Kador, L. Phys. Rev. Lett. 62, 2535–2538 (1989).

    Article  ADS  Google Scholar 

  2. Orrit, M. & Bernard, J. Phys. Rev. Lett. 65, 2716–2719 (1990).

    Article  ADS  Google Scholar 

  3. Tinnefeld, P. & Sauer, M. Angew. Chem. Int. Ed. 44, 2642–2671 (2005).

    Article  Google Scholar 

  4. De Cremer, G., Sels, B. F., De Vos, D. E., Hofkens, J. & Roeffaers, M. B. J. Chem. Soc. Rev. 39, 4703–4717 (2010).

    Article  Google Scholar 

  5. Gaiduk, A., Yorulmaz, M., Ruijgrok, P. V. & Orrit, M. Science 330, 353–356 (2010).

    Article  ADS  Google Scholar 

  6. Kukura, P., Celebrano, M., Renn, A. & Sandoghdar, V. J. Phys. Chem. Lett. 1, 3323–3327 (2010).

    Article  Google Scholar 

  7. Chong, S., Min, W. & Xie, X. S. J. Phys. Chem. Lett. 1, 3316–3322 (2010).

    Article  Google Scholar 

  8. Celebrano, M., Kukura, P., Renn, A. & Sandoghdar, V. Nature Photon. 5, 95–98 (2011).

    Article  ADS  Google Scholar 

  9. Hell, S. W. Science 316, 1153–1158 (2007).

    Article  ADS  Google Scholar 

  10. Hotta, J. I. et al. J. Am. Chem. Soc. 132, 5021–5023 (2010).

    Article  Google Scholar 

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Hofkens, J., Roeffaers, M. Single-molecule light absorption. Nature Photon 5, 80–81 (2011).

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