It has long been thought that the detection of individual molecules in ambient conditions via their absorption signature was out of reach. Now, three independent research groups have developed three different methods that allow such a feat.
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Hofkens, J., Roeffaers, M. Single-molecule light absorption. Nature Photon 5, 80–81 (2011). https://doi.org/10.1038/nphoton.2011.7
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