Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cellular transport

Gatekeepers of the nucleus

This article has been updated

The ambiguous barrier mechanism of nuclear pore complexes has now been resolved through structural analysis with high-speed atomic force microscopy.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Different models for the configuration of the FG Nups barrier at the nuclear pore.

Change history

  • 11 May 2016

    After publication of this News & Views, in Fig. 1, the middle and right-hand illustrations of the nuclear pores were mistakenly swapped. This piece has now been corrected in all versions.

References

  1. Knockenhauer, K. E. & Schwartz, T. U. Cell 164, 1162–1171 (2016).

    CAS  Article  Google Scholar 

  2. Sakiyama, Y., Mazur, A., Kapinos, L. E. & Lim, R. Y. H. Nature Nanotech. 11, 719–723 (2016).

    CAS  Article  Google Scholar 

  3. Denning, D. P., Patel, S. S., Uversky, V., Fink, A. L. & Rexach, M. Proc. Natl Acad. Sci. USA 100, 2450–2455 (2003).

    CAS  Article  Google Scholar 

  4. Adams, R. L. & Wente, S. R. Cell 152, 1218–1221 (2013).

    CAS  Article  Google Scholar 

  5. Frey, S. & Gorlich, D. Cell 130, 512–523 (2007).

    CAS  Article  Google Scholar 

  6. Yamada, J. et al. Mol. Cell Proteom. 9, 2205–2224 (2010).

    CAS  Article  Google Scholar 

  7. Rout, M. P., Aitchison, J. D., Magnasco, M. O. & Chait, B. T. Trends Cell Biol. 13, 622–628 (2003).

    CAS  Article  Google Scholar 

  8. Lim, R. Y. et al. Science 318, 640–643 (2007).

    CAS  Article  Google Scholar 

  9. Dange, T., Grunwald, D., Grunwald, A., Peters, R. & Kubitscheck, U. J. Cell Biol. 183, 77–86 (2008).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Victor Shahin.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Shahin, V. Gatekeepers of the nucleus. Nature Nanotech 11, 658–659 (2016). https://doi.org/10.1038/nnano.2016.74

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nnano.2016.74

Further reading

Search

Quick links

Find nanotechnology articles, nanomaterial data and patents all in one place. Visit Nano by Nature Research