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Molecular computing

In situ computation of cell identity

Nature Nanotechnology volume 8, pages 546–548 (2013)Cite this article

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Cascade reactions can be used to carry out logic operations on the surface of cells and identify the presence of particular collections of cell surface markers.

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Figure 1: A three-input AND gate (A AND B AND C) using a programmed cascade of reactions on a cell surface.

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Authors and Affiliations

  1. and the Department of Systems Biology at Harvard Medical School, Thomas E. Schaus and Peng Yin are at the Wyss Institute of Biologically Inspired Engineering at Harvard University, CLSB, 5th Floor, 3 Blackfan Circle, Boston, Massachusetts 02115, USA, 200 Longwood Avenue, Alpert 536, Boston, Massachusetts 02115, USA,

    Thomas E. Schaus & Peng Yin

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  1. Thomas E. Schaus
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  2. Peng Yin
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Correspondence to Peng Yin.

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Schaus, T., Yin, P. In situ computation of cell identity. Nature Nanotech 8, 546–548 (2013). https://doi.org/10.1038/nnano.2013.155

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